您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Sp-8-CPT-cAMPS
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Sp-8-CPT-cAMPS
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sp-8-CPT-cAMPS图片
CAS NO:129693-13-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Sp-8-CPT-cAMPS,一种 cAMP 类似物,是 cAMP 依赖性蛋白激酶 APKA IPKA II的有效和选择性的激活剂。Sp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
生物活性

Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependentprotein kinas A (PKA I andPKAII). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].

IC50& Target

PKA[1]

体外研究
(In Vitro)

Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells[2].
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells[2].
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis[3].

分子量

487.88

Formula

C16H15ClN5O5PS2

CAS 号

129693-13-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.