Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependentprotein kinas A (PKA I andPKAII). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold^[1][2].

PKA^[1]

Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells^[2].
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells^[2].
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis^[3].

487.88

C₁₆H₁₅ClN₅O₅PS₂

129693-13-6

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Please store the product under the recommended conditions in the Certificate of Analysis.