Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted byA. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells^[1]. Gliotoxin inhibits inducibleNF-κBactivity by preventing IκB degradation, which consequently induces host-cellapoptosis^[2]. Gliotoxin activatesPKAand increases intracellular cAMP concentration; modulates actincytoskeletonrearrangement to facilitateA. fumigatusinternalization into lung epithelial cells^[3].

326.39

Solid

C₁₃H₁₄N₂O₄S₂

67-99-2

• Antibiotics
• Other Antibiotics

Aspergillus fumigatus

Room temperature in continental US; may vary elsewhere.

DMF : 5 mg/mL(15.32 mM;Need ultrasonic and warming)

DMSO : 5 mg/mL(15.32 mM;Need ultrasonic and warming)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。