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Rp-cAMPS
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rp-cAMPS图片
CAS NO:73208-40-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Rp-cAMPS,一种 cAMP 的类似物,是一种 cAMP 诱导的PKA IPKA II活化 (Ki分别为 12.5 μM 和 4.5 μM) 的有效的,竞争性拮抗剂。Rp-cAMPS 耐磷酸二酯酶水解。
生物活性

Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependentPKAI and II(Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

IC50& Target

Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)[1]

体外研究
(In Vitro)

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].

体内研究
(In Vivo)

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].

分子量

345.27

Formula

C10H12N5O5PS

CAS 号

73208-40-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.