CAS NO: | 73208-40-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependentPKAI and II(Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. |
IC50& Target | Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)[1] |
体外研究 (In Vitro) | A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2]. |
体内研究 (In Vivo) | Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2]. |
分子量 | 345.27 |
Formula | C10H12N5O5PS |
CAS 号 | 73208-40-9 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |