Multi-kinase-IN-1 (Compound 11k) 是一种具有抗肿瘤活性的激酶 (kinase) 抑制剂。Multi-kinase-IN-1 诱导细胞凋亡 (apoptosis)，可用于结直肠癌的研究。
| 生物活性 | Multi-kinase-IN-1 (Compound 11k) is a potentkinaseinhibitor with antitumor activity. Multi-kinase-IN-1 induces cellapoptosis, and can be studied for colorectalcancer[1]. |
| IC50& Target | Ron 0.122 μM (IC50) | PDGFRα 0.384 μM (IC50) | c-Src 0.421 μM (IC50) | AXL 0.632 μM (IC50) |
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体外研究
(In Vitro) | Multi-kinase-IN-1 (Compound 11k) (0-5 μg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 μg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 μg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].
Cell Proliferation Assay[1] | Cell Line: | HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells) | | Concentration: | 0.56, 1.67, and 5 μg/mL for HT-29, 10 μg/mL for FHC | | Incubation Time: | 0-72 h | | Result: | Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells. |
Apoptosis Analysis[1] | Cell Line: | HT-29 | | Concentration: | 0.3, 1, and 3 μg/mL | | Incubation Time: | 0-72 h | | Result: | Induced cell apoptosis in a time- and dose-dependent manner. |
Cell Cycle Analysis[1] | Cell Line: | HT-29 | | Concentration: | 0.3, 1, and 3 μg/mL | | Incubation Time: | 48 h | | Result: | Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%). |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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