您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > HOE 140
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
HOE 140
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HOE 140图片
CAS NO:130308-48-4
包装:500μg
市场价:1470元

产品介绍
HOE 140 (HOE-140) 是一种有效且特异性的缓激肽 B2 受体肽拮抗剂，IC50 和 Ki 分别为 1.07 nM 和 0.798 nM。
Cas No.130308-48-4
别名艾替班特; HOE 140
分子式C59H89N19O13S
分子量1304.52
溶解度Soluble to 1 mg/ml in sterile water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

References:
[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.
[2]. George J, et al. Locally Mediated Analgesic Effect of Bradykinin Type 2 Receptor Antagonist HOE 140 During Acute Inflammatory Pain in Rats. J Burn Care Res. 2014 Jan 21.
[3]. Ferreira AP, et al. HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice. Psychopharmacology (Berl). 2014 May;231(9):1935-48.