| CAS NO: | 1204416-97-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Cas No. | 1204416-97-6 |
| Canonical SMILES | CN(C(C(CN1C2=C(C(C3CCCCC3)=C41)C=CC(/C(O)=N/S5(=O)=O)=C2)=CC6=C4C=CC(OC)=C6)=O)CCOCCN5C |
| 分子式 | C32H38N4O6S |
| 分子量 | 606.73 |
| 溶解度 | ≥ 72.8mg/mL in DMSO with gentle warming |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TMC647055 is a potent and selective non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase with EC50 value of 82 nM [1]. Hepatitis C virus (HCV) NS5B polymerase is a RNA-dependant RNA-polymerase that is responsible for viral replication and plays an important role in HCV life cycle. HCV is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1]. TMC647055 is a selective and cell-permeating HCV NS5B inhibitor. In RNA polymerase primer-dependent transcription assay, TMC647055 inhibited HCV NS5B polymerase with IC50 value of 34 nM. In the Huh7-Luc cell line, TMC647055 inhibited the replication of genotype 1b replicon with EC50 values of 77 and 139 nM measured with luciferase readout and qRT-PCR readout, respectively. TMC647055 exhibited high-affinity interaction with NS5B across all genotypes (except for genotype 2b) with median KD value< 35 nM. In Huh7-Luc replicon cells, TMC647055 (750 nM) reduced 30 cell colonies formation. Also, TMC647055 (1.5 μM and 3.75 μM) reduced HCV replicon RNA [2] [3]. References: |
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