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Lauric Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lauric Acid图片
CAS NO:143-07-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议

产品介绍
月桂酸是一种中链游离脂肪酸,具有很强的杀菌作用。
Cas No.143-07-7
别名月桂酸
化学名dodecanoic acid
Canonical SMILESCCCCCCCCCCCC(O)=O
分子式C12H24O2
分子量200.32
溶解度≥ 40.2 mg/mL in DMSO, ≥ 40.4 mg/mL in EtOH
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lauric acid, a saturated medium-chain fatty acid with a 12-carbon backbone, is naturally found in various plant and animal fats and oils, which is a major component of palm kernel oil and coconut oil.

In vitro: Previous study showed that lauric acid could induce apoptosis in both Caco-2 and IEC-6 cells when compared to butyrate. Moreover, lauric acid reduced GSH availability and generated ROS in Caco-2 cells. Mechanistic study indicated that lauric acid reduced Caco-2 and IEC-6 cells in G0/G1and arrested cells in the S and G2/M phases. In addition, it was found that butyrate protected IEC-6 cells from ROS-induced damage, while lauric acid induced higher levels of ROS when compared with butyrate [1].

In vivo: Mouse in vivo study found that both epicutaneous application and intradermal injection of lauric acid could decrease the number of P. acnes colonized in mouse ears effectively, thus relieving P. acnes-induced granulomatous inflammation and ear swelling [2].

Clinical trial: Previous clinical study showed that lauric acid ingestion did not induce nausea or bloating. There was no effect of lauric acid on energy intake at breakfast, energy intake at lunch was reduced significantly after ingestion of lauric acid. In addition, it was observed that the total energy intake (breakfast+lunch+lauric acid dose) was less following ingestion of 6 g of lauric acid compared with control [3].

References:
[1] Fauser JK,Matthews GM,Cummins AG,Howarth GS.  Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress. Chemotherapy.2013;59(3):214-24.
[2] Nakatsuji T,Kao MC,Fang JY,Zouboulis CC,Zhang L,Gallo RL,Huang CM.  Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol.2009 Oct;129(10):2480-8.
[3] Kate L.  Feltrin et al. Acute oral administration of lauric acid reduces energy intake in healthy males. e-SPEN Journal. 2014 April; 9 (2): e69–e75