CAS NO: | 3922-90-5 |
包装 | 价格(元) |
5mg | 电议 |
25mg | 电议 |
Cas No. | 3922-90-5 |
别名 | 竹桃霉素 |
化学名 | 7-(α-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one |
Canonical SMILES | O=C1[C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]([C@H]([C@H](C[C@@]12CO2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@H](C4)OC)O)C)[H])C)=O)C)C)O)C |
分子式 | C35H61NO12 |
分子量 | 687.9 |
溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Oleandomycin is an antibiotic produced by strains of Streptomyces. In vitro: Oleandomycin has been identified as a macrolide antibiotic demonstrating antimicrobial activity similar to penicillin and erythromycin. In addition, oleandomycin structurally has a macrocyclic lactone ring of 14 carbon atoms with one sugar, oleandrose, and one amino sugar, desoxamine [1]. In vivo: The PK of oleandomycin after i.v. and po administration, both alone and after i.m. pretreatment with metamizole or dexamethasone, was studied in healthy dogs. Results showed that after i.v. injection of oleandomycin alone at 10 mg/kg, the t1/2β, Vd, Cl and AUC were 1.60 h, 1.11 L/kg, 7.36 ml/kg/min and 21.66 μg h/ml, respectively. There were no statistically significant differences following pretreatment with metamizole or dexamethasone. In addition, after po administration of oleandomycin alone, the t1/2β, Cmax, tmax), MAT and Fabs were 1.68 h, 5.34 μg/ml, 1.5 h, 1.34 h and 84.29%, respectively, and the pretreatment with metamizole showed a significantly decreased value for Cmax but the MAT was increased significantly. Statistically significant changes in the PK parameters of oleandomycin following po administration were also seen as a result of pretreatment with dexamethasone. The Cmax was increased and the tmax and MAT were lower [2]. Clinical trial: Up to now, oleandomycin is still in the preclinical development stage. References: |