| CAS NO: | 50656-77-4 |
| 包装: | 5mg |
| 市场价: | 6750元 |
| Cas No. | 50656-77-4 |
| 别名 | 珠子草素 |
| 化学名 | rel-6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole |
| Canonical SMILES | COC1=CC(C[C@@H](COC)[C@H](COC)CC2=CC(OC)=C(OC)C=C2)=CC3=C1OCO3 |
| 分子式 | C24H32O7 |
| 分子量 | 432.5 |
| 溶解度 | DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 15.6 μM and 25.1 μM for inhibiting the secretion of HBsAg and HBeAg, respectively. Niranthin is a natural lignin isolated from the genus Phyllanthus, with antiviral activities both in vitro and in vivo. Niranthin also exerts anti-inflammatory and anti-allodynic activities. In Vitro: In human hepatoma cell line MS-G2 which synthesizes hepatitis B viral particles, Niranthin was screened among 25 pure compounds which were isolated from several phyllanthus species with the most potent anti-HBV activity (EC50= 33.6 μM) by effectively suppressing the expression of HBsAg and HBeAg, with the highest inhibition of 74.3% [1]. Besides, in human HBV-transfected liver cell line HepG2.2.15, Niranthin could significantly inhibit the secretion of HBsAg and HBeAg after treatment for 144 h, with the IC50 values of 15.6 μM and 25.1 μM, respectively [2]. In Vivo: In duck hepatitis B virus (DHBV) infected ducks, intragastric administration of Niranthin could significantly decrease the plasma DHBV DNA levels, with the mean inhibition percentage of 70.72%, 75.23%, and 90.87% at the dose of 25, 50, and 100 mg/kg/day, respectively. Niranthin could also significantly inhibit the serum HBsAg, HBeAg, ALT, and AST levels [2]. Clinical trial: no data available. References: |
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