CAS NO: | 923288-90-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent againstBCR-ABL, and is active against manyBCR-ABLmutants. | ||||||||||||||||
IC50& Target | Bcr-Abl[1] | ||||||||||||||||
体外研究 (In Vitro) | Nilotinib (AMN107) monohydrochloride monohydrate, selective Abl inhibitor, is designed to interact with the ATP-binding site of BCR-ABL with a higher affinity than imatinib while being significantly more potent compared with imatinib (IC50<30 nm), also maintains activity against most of the bcr-abl point mutants that confer imatinib resistance[1]. | ||||||||||||||||
体内研究 (In Vivo) | Nilotinib monohydrochloride monohydrate (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft[2].
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Clinical Trial | |||||||||||||||||
分子量 | 583.99 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H25ClF3N7O2 | ||||||||||||||||
CAS 号 | 923288-90-8 | ||||||||||||||||
中文名称 | 尼洛替尼盐酸盐一水合物;尼罗替尼盐酸盐一水合物 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 33 mg/mL(56.51 mM) H2O :< 0.1 mg/mL (ultrasonic)(insoluble) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |