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TD-428
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TD-428图片
CAS NO:2334525-50-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
TD-428是由Cereblon配体和BRD4配体相连的PROTAC。TD-428 是一种高度特异的BRD4降解剂，DC50为 0.32 nM。TD-428 是一种BET PROTAC，其中 TD-106 (CRBN 配体) 连接到 JQ1 (BET 抑制剂)，TD-428 可有效诱导 BET 蛋白降解。
生物活性

TD-428 is aPROTACconnected by ligands forCereblonandBRD4. TD-428 is a highly specificBRD4degrader with aDC50 of 0.32 nM[1]. TD-428 is aBETPROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation[1].

IC50& Target[1]

BRD4

0.32 nM (DC50)

Cereblon

 

体外研究
(In Vitro)

TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1[1].
TD-428 (0.01-10,000 nM; 72 hours) inhibits the proliferation of 22RV1 cells with a CC50 of 20.1 nM[1].
TD-428 (1 nM-10 μM; 12 hours) induces the degradation of BRD4, IKZF1, and IKZF3 proteins[1].

Cell Cytotoxicity Assay[1]

Cell Line:22RV1 cells
Concentration:0.01, 0.1, 1, 10, 100, 1000, and 10000 nM
Incubation Time:72 hours
Result:Inhibited cell proliferation with a CC50 of 20.1 nM.

Western Blot Analysis[1]

Cell Line:U266 cells
Concentration:1 nM, 10 nM, 100 nM, 1000 nM, and 10 μM
Incubation Time:12 hours
Result:Induced the degradation of BRD4, IKZF1, IKZF3 proteins.
分子量

879.38

Formula

C43H43ClN10O7S

CAS 号

2334525-50-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.