包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SJ1008030 (compound 8) is aJAK2PROTACwhich selectively degradesJAK2. SJ1008030 inhibits MHH–CALL-4 cells with anEC50of 5.4 nM and anIC50of 32.09 nM. SJ1008030 can be used for the research of leukemia[1]. | ||||||||||||||||||||||||
IC50& Target | IC50: 32.09 nM (MHH-CALL-4), 33.41 nM (MHH-CALL4-GSPT1-WT), 33.55 nM (MHH-CALL-4-GSPT1-G575N)[1] | ||||||||||||||||||||||||
体外研究 (In Vitro) | SJ1008030 (compound 8) (0-3 μM; 72 h) shows activity in CRLF2r cell lines[1].SJ1008030 (compound 8) (0-4.3 μM; 72 h) shows cytotoxicity to MHH–CALL-4 cells[1].SJ1008030 (compound 8) (0-10000 nM; 24 h) inhibits the JAK-STAT signaling pathway in xenograft SJBALL021415 bone marrow cells[1]. Cell Cytotoxicity Assay[1]
Western Blot Analysis[1]
Western Blot Analysis[1]
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分子量 | 873.94 | ||||||||||||||||||||||||
Formula | C42H43N13O7S | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |