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SJ1008030
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SJ1008030图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SJ1008030 (compound 8) 是一种JAK2 PROTAC选择性地降解JAK2。SJ1008030 对 MHH–CALL-4 细胞系的EC50值为 5.4 nM,IC50值为 32.09 nM。SJ1008030 可用于白血病的研究。
生物活性

SJ1008030 (compound 8) is aJAK2PROTACwhich selectively degradesJAK2. SJ1008030 inhibits MHH–CALL-4 cells with anEC50of 5.4 nM and anIC50of 32.09 nM. SJ1008030 can be used for the research of leukemia[1].

IC50& Target

IC50: 32.09 nM (MHH-CALL-4), 33.41 nM (MHH-CALL4-GSPT1-WT), 33.55 nM (MHH-CALL-4-GSPT1-G575N)[1]

体外研究
(In Vitro)

SJ1008030 (compound 8) (0-3 μM; 72 h) shows activity in CRLF2r cell lines[1].
SJ1008030 (compound 8) (0-4.3 μM; 72 h) shows cytotoxicity to MHH–CALL-4 cells[1].
SJ1008030 (compound 8) (0-10000 nM; 24 h) inhibits the JAK-STAT signaling pathway in xenograft SJBALL021415 bone marrow cells[1].

Cell Cytotoxicity Assay[1]

Cell Line:The CRLF2r cell lines MHH–CALL-4, KOPN49, MHH–CALL-2, KOP N75, NALM-6 and 697
Concentration:0-3 μM
Incubation Time:72 hours
Result:Showed best activity in MHH–CALL-4 cells with an EC50value of 5.4 nM.

Western Blot Analysis[1]

Cell Line:MHH–CALL-4 cells
Concentration:1 nM, 10 nM, 100 nM, 1 μM and 4.3 μM
Incubation Time:72 hours
Result:Significantly degradated JAK2 in MHH–CALL-4 cells dose-dependently while showed weakly effect to JAK1, JAK3 and GSPT1.

Western Blot Analysis[1]

Cell Line:Xenograft SJBALL021415 bone marrow cells
Concentration:1, 10, 100, 1000 and 1000 nM
Incubation Time:24 hours
Result:Near-completely degradated JAK2 in a dose-dependent way while showed no effect on GSPT1.
分子量

873.94

Formula

C42H43N13O7S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.