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PROTAC SOS1 degrader-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTAC SOS1 degrader-3图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PROTAC SOS1 degrader-3 是一种有效的PROTAC SOS1降解剂。PROTAC SOS1 degrader-3 通过泛素-蛋白酶体系统有效靶向 SOS1 进行降解。
生物活性

PROTACSOS1 degrader-3 is a potentPROTACSOS1degrader.PROTACSOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system[1].

IC50& Target[1]

Cereblon

 

SOS1

 

体外研究
(In Vitro)

PROTAC SOS1 degrader-3 (P7; 0.1-10 μM; 6 hours) induces SOS1 degradation in SW620 cells. In addition to SW620, PROTAC SOS1 degrader-3 also induces SOS1 degradation in other colorectal cancer (CRC) cell lines HCT116, C2BB, and SW1417 in a concentration-dependent manner. The half maximal degradation concentration (DC50) for SW620, HCT116, and SW1417 at 24 h is 0.59 μM, 0.75 μM, and 0.19 μM, respectively[1].

Western Blot Analysis[1]

Cell Line:SW620 cells
Concentration:0.1 μM, 1 μM, 10 μM
Incubation Time:6 hours
Result:Induced SOS1 degradation.
分子量

691.66

Formula

C34H32F3N7O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.