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ACBI2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACBI2图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ACBI2 是一种高效且具有口服活性的VHL PROTAC(EC50: 7 nM),可降解SMARCA2(RKO 细胞中DC50: 1 nM)。ACBI2 可用于肺癌的研究。
生物活性

ACBI2 is a highly potent and orally activeVHLPROTAC(EC50: 7 nM), which selectively degradesSMARCA2with aDC50value of 1 nM in RKO cells. ACBI2 can be used in the research of lungcancer[1].

IC50& Target[1]

VHL

7 nM (EC50)

SMARCA2

 

体外研究
(In Vitro)

ACBI2 (0.1 nM-1 μM, 4-18 h) rapidly and completely degrades SMARCA2 in two sensitive cell lines (A549 and NCI-H1568)[1].
ACBI2 (1 nM-1 μM, 18 h) significantly degrades SMARCA2 with clear selectivity over SMARCA4[1].

体内研究
(In Vivo)

ACBI2 (80 mg/kg, p.o., once daily) significantly inhibits tumor growth in an A549 xenograft mice model[1].
ACBI2 (5-100 mg/kg, p.o., tumors collected 24 or 48 h after treatment) dose-dependently degrades SMARCA2 in NCI-H1568 and A549 engrafted tumor bearing mice (IHC staining)[1].
ACBI2 (30 mg/kg, p.o., mice) shows oral bioavailability of 22%[1].

Animal Model:A549 xenograft mice model[1]
Dosage:80 mg/kg
Administration:Oral administration (p.o.), once daily
Result:Inhibited tumor growth and was well tolerated.
分子量

1063.17

Formula

C57H69BrFN7O5S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.