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Modecainide(BMY 40327)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Modecainide(BMY 40327)图片
CAS NO:81329-71-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Modecainide (BMY 40327) 是 Encainide 的主要代谢物,Encainide 是一种抗心律失常药物。
Cas No.81329-71-7
别名莫地卡尼,BMY 40327; MJ 14030
Canonical SMILESO=C(NC1=CC=CC=C1CCC2N(C)CCCC2)C3=CC=C(O)C(OC)=C3
分子式C22H28N2O3
分子量368.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

The effect of Encainide and its two major metabolites, O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway. MJ 9444 (0.05-0.4 mg/kg) speeds Purkinje conduction of early (less than 300 msec) without affecting or while slowing conduction of late (greater than 350 msec) extrasystoles. Higher doses (0.4-1.6 mg/kg) slows conduction at all intervals. The effective refractory period and the functional refractory period are decreased but in some cases returned to control values at the higher doses. Muscle conduction is slowed at doses of 0.4 mg/kg or more. MJ 14030 (0.05-3.2 mg/kg) has variable effects, behaving like MJ 9444 in three experiments but like the parent compound in two others[1].

[1]. Dresel PE. Effect of encainide and its two major metabolites on cardiac conduction. J Pharmacol Exp Ther. 1984 Jan;228(1):180-6.