您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Biotin-PEG3-C3-NH2
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Biotin-PEG3-C3-NH2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biotin-PEG3-C3-NH2图片
CAS NO:183896-00-6
包装与价格:
包装价格(元)
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Biotin-PEG3-C3-NH2 是一种PROTAC linker,属于PEG 类,具有 NH2官能团。可用于合成 PROTAC 分子。
生物活性

Biotin-PEG3-C3-NH2 is a PEG-basedPROTAClinker, with NH2functional group, that can be used in the synthesis ofPROTACs[1].

IC50& Target

PEGs

 

体外研究
(In Vitro)

PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].

分子量

446.60

性状

Oil

Formula

C20H38N4O5S

CAS 号

183896-00-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)