Piperafizine A (compound 4d') 是一种 N-单烷基化普那布林衍生物。抗癌试剂。
| Cas No. | 130603-59-7 |
| Canonical SMILES | O=C(/C(NC/1=O)=C/C2=CC=CC=C2)N(C)C1=C/C3=CC=CC=C3 |
| 分子式 | C19H16N2O2 |
| 分子量 | 304.3 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml. |
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