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Pimprinine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pimprinine图片
CAS NO:13640-26-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.13640-26-1
别名5-(1H-吲哚基)2-甲基噁唑
化学名3-(2-methyl-5-oxazolyl)-1H-indole
Canonical SMILESCC(O1)=NC=C1C2=CNC3=CC=CC=C32
分子式C12H10N2O
分子量198.2
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties. It inhibits deamination of serotonin by monoamine oxidase (MAO; IC50 = 48 μM). Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice. In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml). It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).

References:
[1].Takeuchi, T., Ogawa, K., Iinuma, H., et al. Monoamine oxidase inhibitors isolated from fermented broths J. Antibiot. (Tokyo) 26(3), 162-167 (1973).
[2].Naik, S.R., Harindran, J., and Varde, A.B. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: Fermentation, isolation and pharmacological activity J. Biotechnol. 88(1), 1-10 (2001).
[3].Umehara, K., Yoshida, K., Okamoto, M., et al. Studies on new antiplatelet agents, WS-30581 A and B J. Antibiot. (Tokyo) 37(10), 1153-1160 (1984).
[4].Intaraudom, C., Rachtawee, P., Suvannakad, R., et al. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924 Tetrahedron 67(39), 7593-7597 (2011).