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AC1-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AC1-IN-1图片
CAS NO:2762422-55-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
AC1-IN-1 是一种有效的选择性 AC1 抑制剂，其 IC50 为 0.54 µM. AC1-IN-1 在炎症性疼痛小鼠模型中表现出适度的抗异常疼痛的作用。AC1-IN-1 具有 CNS 活性。
Cas No.2762422-55-7
分子式C18H18FN5O2
分子量355.37
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity[1].

AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line[1].

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point[1].

[1]. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686.