2-氯棕榈酸是一种炎症脂质介质，可干扰蛋白质棕榈酰化，诱导 ER 应激标记，降低 ER ATP 含量，并激活 IL-6 的转录和分泌以及 IL-8.2-氯棕榈酸破坏线粒体膜电位并诱导 procaspase-3 和 PARP 裂解。2-氯棕榈酸可以穿过血脑屏障 (BBB) 并损害人脑内皮细胞系 hCMEC/D3 中的 ER 和线粒体功能。
| Cas No. | 19117-92-1 |
| 别名 | 2-氯十六烷酸 |
| Canonical SMILES | CCCCCCCCCCCCCCC(Cl)C(O)=O |
| 分子式 | C16H31ClO2 |
| 分子量 | 290.9 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells. |
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