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m-PEG3-aldehyde
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG3-aldehyde图片
CAS NO:356066-46-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
m-PEG3-aldehyde 是一种 PROTAC linker (PROTAC linker),属于 PEG 类,可用于合成 PROTACs。
生物活性

m-PEG3-aldehyde is aPEG-basedPROTAClinkercan be used in the synthesis ofPROTACs.

IC50& Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
The binding affinities of anti-mPEGs depend more on the backbone lengths of the polymers and the hydrophobicities of their end-groups than on their resemblance to the methoxy terminus of the immunogenic polymer[1].
Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.

分子量

176.21

Formula

C8H16O4

CAS 号

356066-46-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.