| CAS NO: | 67920-52-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 220.15 |
|---|---|
| Formula | C9H9O5.Na |
| CAS No. | 67920-52-9 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 7 mg/mL (31.8 mM) |
| Water: 2 mg/mL (9.1 mM) | |
| Ethanol: <1 mg/mL | |
| Solubility (In vivo) | Chemical Name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt InChi Key: ZMMKVDBZTXUHFO-UHFFFAOYSA-M InChi Code: InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1 SMILES Code: OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+] |
| Synonyms | Danshensu sodium; Sodium Danshensu; (±)-DanShenSu sodium salt |
| In Vitro | In vitro activity: Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium. Cell Assay: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells |
|---|---|
| In Vivo | Thoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammatio |
| Animal model | Rats |
| Formulation & Dosage | |
| References | Food Chem Toxicol. 2008 Jan;46(1):73-81; Acta Pharmacol Sin. 2010 Apr;31(4):421-8; Toxicol Mech Methods. 2010 Oct;20(8):510-4. |
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