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(S)-MCPG
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(S)-MCPG图片
CAS NO:150145-89-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
(S)-MCPG ((+)-MCPG) 是一种有效的 I/II 组代谢型谷氨酸受体 (mGluRs) 拮抗剂和 (RS)-MCPG 的活性异构体。
Cas No.150145-89-4
别名(+)-MCPG
化学名(R)-4-(1-amino-1-carboxyethyl)benzoic acid
Canonical SMILESOC([C@](C1=CC=C(C(O)=O)C=C1)(C)N)=O
分子式C10H11NO4
分子量209.2
溶解度Soluble to 100 mM in 1.1eq. NaOH
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-MCPG is the active isomer of (RS)-MCPG , non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG.

References:
[1]. Bordi F et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65.
[2]. Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol. 1996 Apr;117(7):1493-503.
[3]. Jane DE et al. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 1993 Jul;32(7):725-7.