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AH 11110 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AH 11110 hydrochloride图片
CAS NO:179388-65-9
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
α1B-AR ligand,subtype-selective
Cas No.179388-65-9
化学名(S)-1-([1,1'-biphenyl]-2-yloxy)-4-imino-4-(piperidin-1-yl)butan-2-ol hydrochloride
Canonical SMILESO[C@H](COC1=CC=CC=C1C2=CC=CC=C2)CC(N3CCCCC3)=N.Cl
分子式C21H26N2O2.HCl
分子量374.91
溶解度Soluble to 25 mM in Water
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AH 11110 hydrochloride is a selective antagonist of α1B-adrenoceptor [1].

α1B-adrenoceptor (α1B-AR) belongs to α1- adrenergic receptors, which include three subtypes α1A, α1B and α1D and play an important role in regulating cell growth and proliferation.

AH 11110 hydrochloride is a selective α1B-AR antagonist. AH11110A inhibited cloned α1B-AR with Ki value of 79.4 nM and exhibited 32- and 26-fold selectivity over α1A- and α1D-ARs, respectively [1]. In rat vas deferens and rat perfused kidney, AH11110A exhibited affinities for α1A-AR, α1B-AR and α1D-AR with pA2 values of 6.41, 5.40-6.54 and 5.47-5.48, respectively. Also, AH11110A displayed affinity for α2-adrenoceptor in rabbit vas deferens with pA2 value of 5.44. In ligand binding studies, AH11110A exhibited affinities for native and cloned α1B-AR with pKi of 7.10-7.73. AH11110A increased contraction of rat vas deferens [2]. In isolated spleen strips from guinea-pig, AH11110A competitively antagonized tissue contraction induced by noradrenaline in a concentration-dependent way [2].

References:
[1].  Erami C, Zhang H, Ho JG, et al. Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. Am J Physiol Heart Circ Physiol, 2002, 283(4): H1577-1587.
[2].  Eltze M, Konig H, Ullrich B, et al. Failure of AH11110A to functionally discriminate between alpha(1)-adrenoceptor subtypes A, B and D or between alpha(1)- and alpha(2)-adrenoceptors. Eur J Pharmacol, 2001, 415(2-3): 265-276.