| CAS NO: | 139180-30-6 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 10mg | 电议 |
| Cas No. | 139180-30-6 |
| 化学名 | 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol |
| Canonical SMILES | OC1=CC=C(C=C1)CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2 |
| 分子式 | C16H15N7O2 |
| 分子量 | 337.34 |
| 溶解度 | DMSO: 100mM,Ethanol: 5 mM |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. ZM241385 (1 μM; 24 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA levels[1].ZM241385 (1 μM; 48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly increases A2AR protein levels[1]. ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC[4]. References: |
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