CAS NO: | 160521-72-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
Cas No. | 160521-72-2 |
别名 | BW723C86盐酸盐 |
化学名 | (R)-1-(5-(thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride |
Canonical SMILES | N[C@H](C)CC(C1=C2)=CNC1=CC=C2OCC3=CC=CS3.Cl |
分子式 | C16H18N2OS.HCl |
分子量 | 322.85 |
溶解度 | DMF: >55 mg/ml,DMSO: >52 mg/ml,Ethanol: >6 mg/ml,PBS pH 7.2: >160 µ g/ml |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | BW 723C86 hydrochloride is a selective agonist of 5-HT2B receptor [1]. The 5-HT2B receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and plays an important role in shape changes in platelets, contraction of blood vessels and neuronal sensitization to tactile stimuli. BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist. BW723C86 reversibly increased both the amplitude and frequency of miniature excitatory postsynaptic currents (mEPSCs) in cardiac vagal neurons (CVNs), which were blocked by P2 receptor antagonist PPADS. And BW723C86 facilitated excitatory purinergic neurotransmission to CVNs via P2X receptor [2]. In a rat social interaction test, BW 723C86 (3 or 10 mg/kg) increased total interaction and induced an anxiolytic-like action, which was mediated by 5-HT2B receptor [1]. In a rat Vogel conflict test, BW 723C86 (10 or 30 mg/kg) increased the number of punishments, which were mediated by 5-HT2B receptor and were consistent with its anxiolytic-like properties [3]. In a neuropathic pain rat model, BW723C86 significantly inhibited mechanical allodynia and cold allodynia in a dose-dependent way [4]. References: |