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GR 159897
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GR 159897图片
CAS NO:158848-32-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
GR 159897 是一种高效、选择性、竞争性、可穿透脑的非肽神经激肽 2 (NK2) 受体拮抗剂。
Cas No.158848-32-9
别名({1-[2-(5-氟-1H-吲哚-3-基)乙基]-4-甲氧基-4-哌啶基}甲基)(苯基)锍醇
化学名5-fluoro-3-(2-(4-methoxy-4-((phenylsulfinyl)methyl)piperidin-1-yl)ethyl)-1H-indole
Canonical SMILESFC1=CC=C2NC=C(C2=C1)CCN3CCC(CC3)(CS(C4=CC=CC=C4)=O)OC
分子式C23H27FN2O2S
分子量414.54
溶解度30mg/ml in DMSO
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity[1].

References:
[1]. Beresford IJ, et al. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8.