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Moxalactam(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Moxalactam(sodium salt)图片
CAS NO:64953-12-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
250mg电议
500mg电议
1g电议

产品介绍
Moxalactam (Latamoxef) 钠盐是一种合成的 oxa-β-lactam 抗生素。
Cas No.64953-12-4
别名拉氧头孢钠; Latamoxef sodium; Lamoxactam sodium; LY-127935 sodium
化学名(6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt
Canonical SMILESOC1=CC=C([C@@H](C([O-])=O)C(N[C@@]2(OC)[C@](OCC(CSC3=NN=NN3C)=C4C([O-])=O)([H])N4C2=O)=O)C=C1.[Na+].[Na+]
分子式C20H18N6O9S o 2Na
分子量564.4
溶解度≥ 25.95mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Moxalactam (sodium salt) is a β-lactam antibiotic.

β-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most β-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam is an oxacephem antibiotic and inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria. Moxalactam was more active against Klebsiella and E coli than cefoperazone. Moxalactam did not inhibit methicillin-resistant S. aureus and Enterococci. Moxalactam had been extremely active against Haemophilis and Neisseria gonorrhoeae. Moxalactam was extremely resistant to hydrolysis by all plasmid and chromosmal β-lactamases [1]. In certain situations, Moxalactam impaired normal hemostasis and prolonged bleeding time [2].

References:
[1].  Neu HC. The in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics. Annu Rev Pharmacol Toxicol. 1982;22:599-642.
[2].  Sattler FR, Weitekamp MR, Ballard JO. Potential for bleeding with the new beta-lactam antibiotics. Ann Intern Med. 1986 Dec;105(6):924-31.