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Germicidin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Germicidin B图片
CAS NO:150973-78-7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.150973-78-7
化学名3-ethyl-4-hydroxy-6-(1-methylethyl)-2H-pyran-2-one
Canonical SMILESO=C1OC(C(C)C)=CC(O)=C1CC
分子式C10H14O3
分子量182.2
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Germicidin is a pyranone antibiotic originally excreted by Streptomyces viridochromogenes NRRL B-1551. Germicidin has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml). Higher concentrations of germicidin inhibited porcine Na+/K+-activated ATPase and retarded the germination of the cress Lepidium sativum with an ID50 of 100 μM. Germicidin was the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture [1].

Germicidins B inhibited germination of S. coelicolor A3(2) spores above 1 μg/ml. The S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (~2.7 × 10-14 g per spore) and contents of germicidins B, C and D were 0.2–0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin. Germicidins functioned as self-germination inhibitors in S. coelicolor A3(2) [2].

References:
[1] PETERSEN F, ZHNER H, METZGER J W, et al.  Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551[J]. The Journal of antibiotics, 1993, 46(7): 1126-1138.
[2] Aoki Y, Matsumoto D, Kawaide H, et al.  Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3 (2)[J]. The Journal of antibiotics, 2011, 64(9): 607-611.