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Fusapyrone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fusapyrone图片
CAS NO:156856-31-4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.156856-31-4
化学名3-(4-deoxy-β-xylo-hexopyranosyl)-2-hydroxy-6-[(3E,5E,8Z)-2-hydroxy-7-(hydroxymethyl)-1,1,5,9,11-pentamethyl-3,5,8-heptadecatrien-1-yl]-2H-pyran-2-one
Canonical SMILESO[C@H]1C[C@@H](CO)O[C@@H](C2=C(O)OC(C(C)(C)C(O)/C=C/C(C)=C/C(CO)/C=C(C)\CC(C)CCCCCC)=CC2=O)[C@@H]1O
分子式C34H54O9
分子量606.8
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fusapyrone, a broad-spectrum antifungal metabolite, is isolated from several Fusarium species.

Structurally, fusapyrone consists of a 4-deoxy-β-xylo-hexopyranosyl C-glycosyl moiety bound to the C-6 of the 2-pyrone ring and a highly functionalized aliphatic chain. Fusapyrone exhibited low zoo-toxicity, as evidenced by a lack of toxicity against Artemia salina. Fusapyrone exerted considerable antifungal activity against several plant mycotoxigenic, pathogenic, and human pathogenic filamentous fungi, including Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, and Aspergillus fumigatus [1]. Additionally, it had been investigated as a useful candidate for the control of postharvest crop diseases, including blocking the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes. However, fusapyrone was found to be ineffective toward yeasts isolated from fruits and plants and not toxic to Artemia salina (brine shrimp). The mechanism of action of fusapyrone is unknown and the structure of fusapyrone was revised in 2006.

In vitro: Up to now, in vitro study of fusapyrone is still in the development stage.

In vivo: Up to now, in vivo study of fusapyrone is still in the development stage.

Reference:
[1].  Favilla, M., Pascale, M., Ricelli, A., Evidente, A., Amalfitano, C., & Altomare, C. Inhibition of Species of the Aspergillus Section Nigri and Ochratoxin a Production in Grapes by Fusapyrone. Applied and Environmental Microbiology.2008; 74(7): 2248-2253.