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Teicoplanin A3-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Teicoplanin A3-1图片
CAS NO:93616-27-4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.93616-27-4
别名替考拉宁A3-1,Antibiotic L 17054
化学名34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-α-D-mannopyranosyl-ristomycin A aglycone
Canonical SMILESC/C(O)=N/[C@]([C@@](O[C@]([C@@]1([H])/C(O)=N/[C@@](C(O)=O)([H])C(C=C(O)C=C2O[C@]3([H])[C@](O)([H])[C@](O)([H])[C@@](O)([H])[C@@](O3)([H])CO)=C2C4=C(O)C=CC([C@](/N=C(O)/[C@@](/N=C(O)\[C@](/N=C(O)/[C@@](/N=C(O)\[C@@](N)([H])C5=CC6=C(O)C=C5)([H])CC7=CC(Cl)=C
分子式C72H68Cl2N8O28
分子量1564.3
溶解度Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria.

Teicoplanin A3-1 is a common degradation product of teicoplanins A2-1 to 5, which results from cleavage of the lipoaminoglycoside substituents. Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus which are effective against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and E. faecalis. As an antibiotic complex, teicoplanin consists of five closely related factors, T-A2-1, 2, 3, 4 and 5 and a more polar factor, T-A3-1. Additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in Bacillus subtilis, which is accompanied by an intracellular accumulation of UDP-N-acetylmuramyl-pentapetide [1]. Due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2].

In vitro: Up to now, in vitro study of Teicoplanin A3-1 is still in the development stage.

In vivo: Up to now, in vivo study of Teicoplanin A3-1 is still in the development stage.

References:
[1].  Somma, S., Gastaldo, L., & Corti, A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy. 1984; 26(6): 917-923.
[2].  Traina, G., & Bonati, M. Pharmacokinetics of teicoplanin in man after intravenous administration. Journal of Pharmacokinetics and Biopharmaceutics. 1984;12(2): 119-128.