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Cefoxitin(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefoxitin(sodium salt)图片
CAS NO:33564-30-6
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍
头孢西丁(钠盐)(MK-306)是一种头霉素类抗生素,常与第二代头孢菌素并列,通过干扰细胞壁合成起作用,其活性谱包括广泛的革兰氏阴性菌和革兰氏阳性菌。
Cas No.33564-30-6
别名头孢西丁钠; MK-306
化学名(6R,7S)-3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
Canonical SMILESO=C1[C@](NC(CC2=CC=CS2)=O)(OC)[C@]3([H])N1C(C([O-])=O)=C(COC(N)=O)CS3.[Na+]
分子式C16H16N3O7S2o Na
分子量449.4
溶解度≥ 12.9mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin, 3-carbamoyloxymethyl-7-a-methoxy-7- [2-(2-thienyl)acetamido]-3-cephem-4-carboxylic acid, is a semisynthetic cephamycin antibiotic with broad-spectrum activity. Cefoxitin is also active in vivo against a wide variety of bacteria including penicillin-resistant staphylococci and effective against gram-negative organisms including strains of indole-positive Proteus [1].

In mice, cefoxitin was more active against the cephalosporin-sensitive gram-negative bacteria, strains of E.coli, indole-producing Proteus, and Serratia, and the lactamase producing 2646. Cefoxitin was degraded by the lactamase of E. cloacae at a much slower rate than are the cephalosporins. In pharmacological studies, cefoxitin was found in sera and detected in urine samples in amounts greater than those of cephalothin and less than those of cephaloridine [1].

References:
[1].  Miller AK, Celozzi E, Kong Y, et al. Cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation. Antimicrob Agents Chemother. 1974 Jan;5(1):33-7.
[2].  Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev.2009 Jan;22(1):161-82.