| CAS NO: | 110655-58-8 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 110655-58-8 |
| 别名 | 肉桂霉素,Lanthiopeptin,NSC 71936,Ro 09-0198 |
| 化学名 | L-cysteinyl-L-arginyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-a-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-m |
| Canonical SMILES | O=C([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@@H]([C@H](C)SC[C@H](NC([C@H](N2)CSC3)=O)C4=O)NC([C@H](CC5=CC=CC=C5)NC([C@H]6N(C(CNC([C@@H](NC([C@H](CNCCCC[C@@H](C(O)=O)N7)N4)=O)CC8=CC=CC=C8)=O)=O)CCC6)=O)=O)=O)=O)N[C@@H]3C(N[C@@H]([C@@H](O)C(O)=O)C(NCC(N |
| 分子式 | C89H125N25O25S3 |
| 分子量 | 2041.3 |
| 溶解度 | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cinnamycin is a tricyclic antibiotic. Cinnamycin, a tetracyclic lantibiotic, is produced from S. cinnamoneus containing four unusual amino acids: mesolanthionine, erythro-β-hydroxyaspartic acid, threo-β-methyllanthionine and lysinoalanine. In vitro: A previous study indicated that cinnamycin could exclusively bind to ethanolamine phospholipids, such as PE and ethanolamine plasmalogen. Model membrane study showed that the binding of cinnamycin to PE-containing liposomes was dependent on membrane curvature. The binding of cinnamycin to multilamellar liposomes induced tubulation of membranes, as demonstrated by electron microscopy and small-angle x-ray scattering [1]. In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: A retrospective survey of patients treated with clindamycin for a soft tissue infection was conducted to evaluated whether the incidence of serious side effects was sufficient to preclude the use of this antibiotic. Thirteen patients were found to have severe diarrhoea and 2 of these required inpatient treatment. Certain limitations of the use of clindamycin were suggested but, it was concluded that cinnamycin still has a useful role to play in the treatment of acute soft tissue infection [2]. References: |
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