| CAS NO: | 96736-11-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 96736-11-7 |
| 别名 | 链丝菌素硫酸盐,clonNAT,Streptothricin |
| 化学名 | nourseothricin, monosulfate |
| Canonical SMILES | O[C@@H]1[C@@H](OC(N)=O)[C@@H](CO)O[C@@H](NC2=N[C@@]3([H])[C@](C(NC[C@H]3O)=O)([H])N2)[C@@H]1NC(C[C@@H](N)CCCN[H])=O.O=S(O)(O)=O |
| 分子式 | C31H58N12O10o C19H34N8O8o H2SO4 |
| 分子量 | 1359.5 |
| 溶解度 | ≤10mg/ml in PBS, pH 7.2 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nourseothricin is a broad-spectrum antibiotic. Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei. In vitro: Nourseothricin, represents a mixture of streptothricins, mainly D and F. Although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. In addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1]. In vivo: Animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. Renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. Following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. There was a high degree of accumulation of nourseothricin in renal cortical slices. In contrast to PAH accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. Age dependent differences in nourseothricin accumulation did not exist [2]. Clinical trial: So far, no clinical study has been conducted. References: |
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