| CAS NO: | 1501-84-4 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1501-84-4 |
| 别名 | 盐酸金刚乙胺 |
| 化学名 | (R)-1-((1s,3R,5S,7S)-adamantan-1-yl)ethanamine hydrochloride |
| Canonical SMILES | N[C@H](C)[C@]1(C[C@H]2C3)C[C@@H](C2)C[C@H]3C1.Cl |
| 分子式 | C12H22ClN |
| 分子量 | 215.76 |
| 溶解度 | ≥ 21.6mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. In a variety of tissue culture systems, rimantadine (25 μg/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL). Rimantadine significantly inhibited dengue virus replication in cultures of rhesus monkey PBL. In virus-infected LLC-MK2 cell cultures, rimantadine decreased the production of all four types of dengue virus [1]. Rimantadine interfered with the generation of cellular immune responses. Rimantadine hydrochloride inhibited the proliferative response of human peripheral blood lymphocytes to mitogenic and antigenic stimulation. Rimantadine hydrochloride (25 μg/ml) suppressed the responses to phytohemagglutinin, pokeweed mitogen, and concanavalin A by 25, 65, and 90%, respectively. rimantadine (10 μg/ml) significantly inhibited responses to streptokinase-streptodornase, tetanus toxoid, and A2/Aichi influenza vaccine [2]. In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine (200 mg/day for 5 days) significantly reduced nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms [3]. References: |
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