| CAS NO: | 54-47-7 |
| 包装: | 1g |
| 市场价: | 350元 |
| Cas No. | 54-47-7 |
| 别名 | 磷酸吡哆醛; Pyridoxal 5′-phosphate; Pyridoxyl phosphate |
| 化学名 | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate |
| Canonical SMILES | CC1=C(O)C(C=O)=C(COP(O)(O)=O)C=N1 |
| 分子式 | C8H10NO6P |
| 分子量 | 247.14 |
| 溶解度 | ≥ 12.35mg/mL in DMSO with ultrasonic and warming |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Pyridoxal phosphate results in an imnediate reduction in the rate of DNA synthesis[1]. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost[2]. References: |
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