CAS NO: | 6415-59-4 |
包装 | 价格(元) |
5mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 6415-59-4 |
别名 | 新蛇床内酯 |
化学名 | 3-butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone |
Canonical SMILES | O=C1OC(CCCC)C2CCCC=C21 |
分子式 | C12H18O2 |
分子量 | 194.3 |
溶解度 | ≥ 6.65mg/mL in DMSO |
储存条件 | Store at -20℃, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Sedanolide is a natural compound produced in edible umbelliferous plants, such as Celery seed oil [1]. In HepG2 and CaCo-2 cells, treatment with sedanolide (7-500 μM) for 24h showed no effect on cell viability. In HepG2 cells cultured in sedanolide-free medium, sedanolide (500 μM) treatment for 72h decreased cell viability. Pretreatment with sedanolide (100 μM) for 24 h and exposement to either H2O2 or tBOOH did not exhibit statistically significant difference in viability from controls. In HepG2 following 24-h incubation with 500 μM sedanolide, a significant increase in DNA strand breaks was observed. Sedanolide did not modulate H2O2- and tBOOH-induced DNA damage. Sedanolide was relatively nontoxic to cells in culture [1]. Sedanolide (SN) possesses antioxidant effects. In human liver cancer (J5) cells, treatment with sedanolide suppressed J5 cell viability by inducing autophagy. Sedanolide decreased protein expression levels of phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt and increased PI3K-III, LC3-II and Beclin-1 protein levels. Sedanolide increased the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB. Sedanolide induced J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells [2]. Sedanolide (100 μg/ml) inhibited cyclooxygenases-1 and -2 at 250 pg/ml and blocked topoisomerase-I and-II activity [3]. References: |