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Bafilomycin B1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bafilomycin B1图片
CAS NO:88899-56-3
包装与价格:
包装价格(元)
100μg电议
1mg电议
5mg电议

产品介绍
Bafilomycin B1 是一种从 Streptomyces sp 中分离出来的大环内酯类抗生素,可抑制革兰氏阳性细菌和真菌,并作为 K+- 依赖于大肠杆菌的 ATPase 的抑制剂。
Cas No.88899-56-3
别名巴佛洛霉素 B1
Canonical SMILESC[C@H]([C@@](C[C@H]1OC(/C=C/C(NC(C(CC2)=O)=C2O)=O)=O)(O[C@H](C(C)C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C3)=O)([H])[C@H](/C=C/C=C3\C)OC)C
分子式C44H65NO13
分子量816
溶解度DMSO: Soluble,Methanol: Unstable
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi. Bafilomycin B1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. When used at 100 nM, the related macrolide bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation. Remarkably, at only 1 nM, both bafilomycin A1 or B1 dramatically attenuate chloroquine-induced apoptosis of neurons without altering autophagy.