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Tesaglitazar
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tesaglitazar图片
CAS NO:251565-85-2
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Tesaglitazar 是一种双重过氧化物酶体增殖物激活受体 (PPAR) α/γ 激动剂,对 PPARγ 比对 PPARα 更有效,对大鼠 PPARα 和人 PPARα 的 EC50 分别为 13.4 μM 和 3.6 μM,对大鼠均约为 0.2 μM和人类 PPARγ。
Cas No.251565-85-2
别名(S)-2-乙氧基-3-{4-[2-(4-甲磺酰基苯基)-乙氧基-苯基]-丙酸
化学名(S)-2-ethoxy-3-(4-(4-((methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid
Canonical SMILESOC([C@H](CC(C=C1)=CC=C1OCCC(C=C2)=CC=C2OS(=O)(C)=O)OCC)=O
分子式C20H24O7S
分子量408.47
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].

References:
[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.