| CAS NO: | 35286-58-9 |
| 包装: | 20mg |
| 市场价: | 3476元 |
| Cas No. | 35286-58-9 |
| 别名 | 地榆皂苷 I |
| Canonical SMILES | C[C@]1([H])CC[C@]2(C(O[C@@]3([H])[C@@](O)([H])[C@](O)([H])[C@@](O)([H])[C@@](O3)([H])CO)=O)CC[C@@]4(C([C@]2([H])[C@@]1(O)C)=CC[C@]5([H])[C@]6(CC[C@@](O[C@@]7([H])[C@@](O)([H])[C@](O)([H])[C@](O)([H])CO7)([H])C(C)([C@]6([H])CC[C@]54C)C)C)C |
| 分子式 | C41H66O13 |
| 分子量 | 766.96 |
| 溶解度 | ≥ 76.7mg/mL in DMSO |
| 储存条件 | -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1].Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2]. Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 μM in MDA-MB-231 cells[2].Ziyuglycoside I (5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM[2].Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression[2]. References: |
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