| CAS NO: | 35286-59-0 |
| 包装: | 20mg |
| 市场价: | 1620元 |
| Cas No. | 35286-59-0 |
| 别名 | 地榆皂苷II |
| 化学名 | (1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid |
| Canonical SMILES | C[C@]1([H])CC[C@]2(C(O)=O)CC[C@@]3(C([C@]2([H])[C@@]1(O)C)=CC[C@]4([H])[C@]5(CC[C@@](O[C@@]6([H])[C@@](O)([H])[C@](O)([H])[C@](O)([H])CO6)([H])C(C)([C@]5([H])CC[C@]43C)C)C)C |
| 分子式 | C35H56O8 |
| 分子量 | 604.81 |
| 溶解度 | <6.05mg/mL in DMSO, Limited solubility in EtOH |
| 储存条件 | -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1]. Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1]. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1]. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1].Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1]. References: |
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