CAS NO: | 36839-55-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | 1,2-Bis(2-iodoethoxy)ethane is a PEG-basedPROTAClinker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potentPROTACBTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1]. | |
IC50& Target[1] |
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体外研究 (In Vitro) | 1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802(HY-122562) has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1]. | |
分子量 | 369.97 | |
性状 | Liquid | |
Formula | C6H12I2O2 | |
CAS 号 | 36839-55-1 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |