(R)-4-氨基-3-(4-氯苯基)丁酸

产品名称：

69308-37-8
(R)-Baclofen
(R)-巴氯芬
(R)-4-Amino-3-(4-chlorophenyl)butyric Acid
(R)-4-氨基-3-(4-氯苯基)丁酸

产品介绍：

基本信息

分子式	C₁₀H₁₂ClNO₂
分子量	213.66
MDL编码	MFCD01321057
存储条件	Freezer -20℃

产品描述

(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。

靶点（IC50 & Targe）

GABAR

体外研究

Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.

参考文献

[1] Falch E, et al. J Neurochem, 1986, 47(3), 898-903.

[2] Penn RD, et al. Lancet, 1984, 1(8385), 1078.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P330 P391 P501
UN号码	3077
危险分类	9
包装等级	III
WGK	3