SW044248

基本信息

产品描述

SW-044248是非经典的Topo1抑制剂，对非小细胞肺癌细胞具有选择性毒性作用。

靶点（IC50 & Targe）

Topo I

体外研究

SW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage[1].

细胞实验

Cell lines: NSCLC cell lines

Concentrations: --

Incubation Time: 96 h

Method:Cell viability assay

(Only for Reference)

参考文献

[1] Iryna O. Zubovych, et al. Mol Cancer Ther. 2016, 15(1): 23-36.