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JW 55

品牌
J&K
CAS
664993-53-7
货号
1445468
规格纯度
99%, 一种有效的选择性 β-catenin 抑制剂, 通过抑制端锚聚合酶 (tankyrase 1 和 tankyrase 2, TNKS1/2) 发挥作用
参考价格
795 *本价格含增值税费
促销
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数量
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产品名称:
664993-53-7
JW 55
产品介绍:

基本信息

分子式C25H26N2O5
分子量434.48
存储条件Freezer -20℃

产品描述

JW55是一种有效的、选择性经典Wnt信号通路抑制剂,通过抑制TNKS1/2的PARP区域发挥作用。

靶点(IC50 & Targe)

TNKS1,1.9μM

TNKS2,830nM

体外研究

JW55 inhibits the PARP domain of TNKS1/2, leading to the stabilization of AXIN2 followed by increased degradation of β-catenin. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC50 value of 470 nmol/L. JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 μmol/L and 830 nmol/L, respectively. JW55-mediated inhibition of canonical Wnt signaling results in reduced cell-cycle progression, proliferation, and colony formation in the CRC cell line SW480 in vitro[1].

体内研究

JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and tamoxifen-induced polyposis formation in conditional APC mutant mice[1].

细胞实验

Cell lines: SW480 cells

Concentrations: 10, 5, or 1 μmol/L

Incubation Time: 9 days

Method:--

(Only for Reference)

动物实验

Animal Models: Apc(CKO/CKO)Lgr5-CreERT2+ mice

Formulation: DMSO

Dosages: 100 mg/kg

Administration: oral

(Only for Reference)

参考文献

[1] Waaler J, et al. Cancer Res. 2012, 72(11):2822-32.

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
P302+P352

百灵威科技

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