蛋白质/抗原/多肽 >> 重组蛋白
重组17号染色体开放阅读框42蛋白
产品介绍 基因名: C17orf49 产品别名: BAP18; HEPIS; C17orf49; chromosome 17 open reading frame 49; chromosome 17 open reading frame 49; chromatin complexes subunit BAP18; BPTF-associated protein of 18 kDa; MLL1/MLL complex subunit C17orf49; human embryo lung cellular protein interacting with SARS-CoV nsp-10; 17号染色体开放阅读框42; 17号染色体开放阅读框49; 背景信息: C17orf42 is a 360 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. 标签:His-tag |
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