产品介绍 基因名: GALNT13 产品别名: GalNAc-T13; GALNT13; polypeptide N-acetylgalactosaminyltransferase 13; polypeptide N-acetylgalactosaminyltransferase 13; polypeptide N-acetylgalactosaminyltransferase 13; GalNAc transferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13); polypeptide GalNAc transferase 13; polypeptide N-acetylgalactosaminyltransferase 13 variant delta39bpEx9; polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx2-7; polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 delta39bpEx9; polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 deltaEx8 delta39bpEx9; polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx8; polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx9; pp-GaNTase 13; protein-UDP acetylgalactosaminyltransferase 13; 背景信息: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T13 (Polypeptide N-acetylgalactosaminyltransferase 13), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, is a 556 amino acid protein that displays much stronger enzymatic activity than GalNAc-1 towards GalNAc transfer to mucin peptides such as Muc5a and Muc7. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. With specific expression in the central nervous system, GalNAc-T13 may be responsible for the synthesis of Tn antigen in neuronal cells, which is a universal carcinoma marker on malignant cells. 标签:His-tag |
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