蛋白质/抗原/多肽 >> 重组蛋白
重组EFCAB4B蛋白
产品介绍 基因名: Yipf2 产品别名: 1300010K09Rik; Yipf2; Yip1 domain family, member 2; Yip1 domain family, member 2; protein YIPF2; EFCAB4B蛋白; 背景信息: EF-CAB4B is a 395 amino acid protein belonging to the EF-CAB4 family. Localizing to cytoplasm, EF-CAB4B contains two EF-hand domains and exists as two alternatively spliced isoforms. At low Ca2+ concentrations, EF-CAB4B acts as a calcium-sensor, facilitating the clustering of Orai1 and Stim1 at the junctional regions between plasma membrane and endoplasmic reticulum, leading to regulation of CRAC channel activation. The gene encoding EF-CAB4B maps to human chromosome 12p13.32. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. 标签:His-tag |
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