eIF1AD is a 165 amino acid protein that belongs to the eIF1AD family and contains one S1-like domain. eIF1AD localizes to nucleus and is expressed in the glioblastoma cell line U-87 MG, the embryonic kidney cell line HEK-293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562. eIF1AD interacts with GAPDH and may function to reduce cell proliferation. The gene encoding eIF1AD maps to human chromosome 11q13.1. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in chromosome 11.