蛋白质/抗原/多肽 >> 重组蛋白
重组雄激素受体辅活化因子267kda蛋白
产品介绍 基因名: Nsd1 产品别名: AI528500; KMT3B; Nsd1; nuclear receptor-binding SET-domain protein 1; nuclear receptor-binding SET-domain protein 1; histone-lysine N-methyltransferase, H3 lysine-36 specific; H3-K36-HMTase; H4-K20-HMTase; NR-binding SET domain-containing protein; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; nuclear receptor-binding SET domain-containing protein 1; 雄激素受体辅活化因子267kda蛋白; 背景信息: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 标签:His-tag |
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